Rishwanth Raghu

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Hi! I’m a Ph.D. student in Computer Science at Princeton University, advised by Professor Ellen D. Zhong.

I am broadly interested in the application of ML to problems in structural biology. In particular, my research focuses on the 3D reconstruction of dynamic protein structure from cryo-EM and cryo-ET imaging data.

I’m fortunate to have interned at the Chan Zuckerberg Imaging Institute and the Bhabha+Ekiert Lab. Previously, I completed my B.S.E. and M.S.E. at Princeton University.

Scholar / GitHub / LinkedIn
rraghu [at] princeton [dot] edu

Publications

* denotes equal contribution
  1. cryoboltz_ab.png
    Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data
    Rishwanth Raghu, Axel Levy, Gordon Wetzstein, and Ellen D. Zhong
    arXiv, 2025
    Preprint
  2. drgnai_tomogram.png
    End-to-end neural ab initio reconstruction of challenging cryo-EM and cryo-ET datasets
    Axel Levy, Rishwanth Raghu, J. Ryan Feathers, Michal Grzadkowski, Frédéric Poitevin, Jake D. Johnston, Francesca Vallese, Oliver Biggs Clarke, Gordon Wetzstein, and Ellen D. Zhong
    Nature Methods, 2025 (In Press)
    Preprint
  3. polartube.png
    Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites
    Mahrukh Usmani, Nicolas Coudray, Margot Riggi, Rishwanth Raghu, Harshita Ramchandani, Daija Bobe, Mykhailo Kopylov, Ellen D. Zhong, Janet H. Iwasa, Damian Charles Ekiert, and Gira Bhabha
    PNAS, 2025
    Paper
  4. hydra.png
    Mixture of neural fields for heterogeneous reconstruction in cryo-EM
    Axel Levy*, Rishwanth Raghu*, David Shustin*, Adele Rui-Yang Peng, Huan Li, Oliver Biggs Clarke, Gordon Wetzstein, and Ellen D. Zhong
    NeurIPS, 2024
    Paper Code Website
  5. cryobench.png
    CryoBench: Diverse and challenging datasets for the heterogeneity problem in cryo-EM
    Minkyu Jeon, Rishwanth Raghu, Miro Astore, Geoffrey Woollard, Ryan Feathers, Alkin Kaz, Sonya M. Hanson, Pilar Cossio, and Ellen D. Zhong
    NeurIPS, 2024 (Spotlight)
    Paper Code Website
  6. yturc.jpg
    Conformational states of the microtubule nucleator, the γ-tubulin ring complex
    Brianna Romer, Sophie M. Travis, Brian P. Mahon, Collin T. McManus, Philip D. Jeffrey, Nicholas Coudray, Rishwanth Raghu, Michael J. Rale, Ellen D. Zhong, Gira Bhabha, and Sabine Petry
    bioRxiv, 2023
    Preprint